Product Datasheet
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| Product Description |
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| Product: |
Kininogen, Two Chain HMW, Human Plasma |
| Catalog Number: |
HK-TC |
| Product Page: |
https://www.mol-innov.com/products/IHUKNGTCHMW1MG |
| Description: |
HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a nonenzymatic cofactor of the contact activation system of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogen links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor alpha-Xlla. Kininogen also forms a complex with Factor XI and accelerates its activation to XIa by alpha-Xlla. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease. The two chain form is prepared by kallikrein digestion of single chain kininogen. Two chain kininogen repurified to remove traces of kallikrein and is kinin free. >95percent pure by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol. Prepared from plasma found negative by FDA accepted
methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease). |
| Recommended Storage: |
SAMPLE |
| Minimum Shelf Life: |
242.25 |
| Source: |
2.0 mg/ml |
| Molecular Weight: |
Proteins |
| Extinction Coefficient: |
120,000 |
| Antigen: |
-70 C |
| Target: |
Frozen liquid |
| Target Molecular Weight: |
KININOGEN |
| Host: |
760 |
| Clonality: |
5 |
| Isotype: |
Human plasma |
| Applications: |
Dry ice |
| Cross-reactivity: |
3 years from delivery |
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| Sample Characteristics |
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| Lot Number: |
HK-TC-IHUKNGTCHMW5MG |
| Aliquot: |
1 x Human Kininogen Two Chain Purified High Molecular Weight 5mg |
| Concentration: |
255 |
| Volume: |
800 |
| Titer: |
0.004M Sodium Acetate; 0.15M NaCl; pH 5.3 |
| Buffer: |
SAMPLE |
| Form: |
1.0 mg |
| Preservative: |
0.5 ml |
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| Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
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| For in vitro laboratory use only |
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Molecular Innovations, Inc. - 46430 Peary Court, Novi, MI 48377, USA
Tel: (888) 557-5055 - Fax: (248) 896-0148 - info@mol-innov.com |