Product Datasheet
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| Product Description |
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| Product: |
Human PAI-1 (vitronectin binding negative mutant, wild type active fraction) |
| Catalog Number: |
HPAI-QR |
| Product Page: |
https://www.mol-innov.com/products/IHUPAI1ARWTVN500UG |
| Description: |
A double mutation (Q123K and R101A) results in greatly reduced binding of the PAI-1 mutant to the important ligand vitronectin. All other aspects of PAI-1 biological activity such as anti-protease activity remain unaffected.
References
Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal. Jensen JK, Durand MK, Skeldal S, Dupont DM, Bødker JS, Wind T, Andreasen PA. FEBS Lett. 2004 Jan 2;556(1-3):175-9.
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1. Zhi Xu, Rashna D. Balsara, Natalia V. Gorlatova, Daniel A. Lawrence, Francis J. Castellino, and Victoria A. Ploplis. J. Biol. Chem., Apr 2004; 279:17914-20. |
| Recommended Storage: |
SAMPLE |
| Minimum Shelf Life: |
500.50 |
| Source: |
2.5 mg/ml |
| Molecular Weight: |
Proteins |
| Extinction Coefficient: |
43,000 |
| Antigen: |
-70 C |
| Target: |
Frozen liquid |
| Target Molecular Weight: |
PAI-1 |
| Host: |
819 |
| Clonality: |
30 |
| Isotype: |
E. coli |
| Clone: |
s |
| Applications: |
Dry ice |
| Cross-reactivity: |
3 years from delivery |
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| Sample Characteristics |
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| Lot Number: |
HPAI-QR-IHUPAI1ARWTVN1MG |
| Aliquot: |
1 x Human PAI-1 Recombinant Wild Type Active Vitronectin Binding Negative 1 mg |
| Concentration: |
715 |
| Volume: |
1170 |
| Titer: |
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 |
| Buffer: |
SAMPLE |
| Form: |
0.5 mg |
| Preservative: |
0.2 ml |
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| Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
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| For in vitro laboratory use only |
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Molecular Innovations, Inc. - 46430 Peary Court, Novi, MI 48377, USA
Tel: (888) 557-5055 - Fax: (248) 896-0148 - info@mol-innov.com |