Product Datasheet
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| Product Description |
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| Product: |
Non-enzymatic Human tPA |
| Catalog Number: |
HTPA-ALA |
| Product Page: |
https://www.mol-innov.com/products/IHUTPANE100UG |
| Description: |
This human tPA has an active site serine to alanine mutation which renders it catalytically inactive. The mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). It is >90percent single chain and retains exosite binding as well as other properties of wild type tPA. Recombinantly produced in insect cells.
Reference:
Identification of a conformationally distinct form of plasminogen
activator inhibitor-1, acting as a noninhibitory substrate for tissue-
type plasminogen activator
PJ Declerck, M De Mol, DE Vaughan, and D Collen
J. Biol. Chem., Jun 1992; 267: 11693 - 11696. |
| Recommended Storage: |
SAMPLE |
| Minimum Shelf Life: |
234.50 |
| Source: |
2.0 mg/ml |
| Molecular Weight: |
Proteins |
| Extinction Coefficient: |
70,000 |
| Antigen: |
-70 C |
| Target: |
Frozen liquid |
| Target Molecular Weight: |
tPA (TISSUE PLASMINOGEN ACTIVATOR) |
| Host: |
1865.5 |
| Clonality: |
30 |
| Isotype: |
Insect cell culture |
| Applications: |
Dry ice |
| Cross-reactivity: |
3 years from delivery |
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| Sample Characteristics |
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| Lot Number: |
HTPA-ALA-IHUTPANE1MG |
| Aliquot: |
1 x Human tPA Purified Non-Enzymatic 1mg |
| Concentration: |
335 |
| Volume: |
2665 |
| Titer: |
0.4M HEPES; 0.1M NaCl; pH 7.4 |
| Buffer: |
SAMPLE |
| Form: |
0.1 mg |
| Preservative: |
0.05 ml |
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| Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
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| For in vitro laboratory use only |
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Molecular Innovations, Inc. - 46430 Peary Court, Novi, MI 48377, USA
Tel: (888) 557-5055 - Fax: (248) 896-0148 - info@mol-innov.com |