Product Datasheet
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| Product Description |
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| Product: |
Mouse PAI-1 genetically deficient plasma, sodium citrate |
| Catalog Number: |
MPAI-KO-SC |
| Product Page: |
https://www.mol-innov.com/products/IMSPAI1GDPNAC50UL |
| Description: |
This plasma is an ideal negative control for ELISA based assays and other experiments involving PAI-1. Collected from homozygous PAI-1 knockout mice of strain B6.129S2-Serpine1 tm1Mlg /J. Anticoagulated with sodium citrate and flash frozen. Collected from male mice. Female mouse plasma is also available.
The targeted PAI-1 knockout mutation was made on the C57BL/6J background strain. Mice homozygous for this mutation develop normally and are viable and fertile. Compared to wild type mice, pulmonary clot lysis is increased in the heterozygote and further increased in the homozygote. Endotoxin induced venous thrombosis is decreased compared to wild type mice. Thus, disruption of the Serpine1 gene induces a mild hyperfibrinolytic state. Hemostasis is normal in homozygous mutants.
References:
Carmeliet P; Kieckens L; Schoonjans L; Ream B; van Nuffelen A; Prendergast G; Cole M; Bronson R; Collen D; Mulligan RC. 1993. Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest 92(6):2746-55. |
| Recommended Storage: |
SAMPLE |
| Minimum Shelf Life: |
38.50 |
| Molecular Weight: |
Proteins |
| Antigen: |
-70 C |
| Target: |
Frozen liquid |
| Target Molecular Weight: |
PAI-1 KNOCKOUT MOUSE PLASMA AND ORGANS |
| Host: |
70 |
| Clonality: |
30 |
| Isotype: |
PAI-1 knockout mouse |
| Applications: |
Dry ice |
| Cross-reactivity: |
3 years from delivery |
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| Sample Characteristics |
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| Lot Number: |
MPAI-KO-SC-IMSPAI1GDPNAC100UL |
| Aliquot: |
1 x Mouse PAI-1 Genetically Deficient Plasma 100ul |
| Concentration: |
55 |
| Volume: |
100 |
| Buffer: |
SAMPLE |
| Form: |
0.05 ml |
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| Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
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| For in vitro laboratory use only |
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Molecular Innovations, Inc. - 46430 Peary Court, Novi, MI 48377, USA
Tel: (888) 557-5055 - Fax: (248) 896-0148 - info@mol-innov.com |