Hemophilia B Mouse Model

Molecular Innovations would like to introduce our hemophilia B mouse model. This model was created by targeted disruption of Factor IX using programed nuclease. Mutations are confirmed by PCR genotyping, Sanger sequencing, and RT-PCR. Male hemizygotes display severe hemophilia B phenotype with prolonged blood clotting time and exhibit death after tail clipping without cauterizing. This hemophilia B mouse model will be useful for studying gene therapy methods.

Our hemophilia B mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

DETAILS

Strain background: C57BL/6J
Chromosome: X
Gene: FIX
Targeted Exon: Exon 1
Mutation: 2 bp deletion on Exon 1 creating a premature stop codon (null/complete knockout)
Phenotype:  bleeding disorder (prolonged clotting time (aPTT), tail clipping induced mortality)

Click here to order strain C57BL/6J Hemophilia B mice.

We also provide custom Knockout Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.