Monoclonal antibody produced in mouse. Useful for ELISA and western blot under non-reducing conditions. Binds to an epitope on the C-terminus of VLDL receptor ligand binding domain (amino acids 191-355, UniProtKB: locus VLDLR_HUMAN, accession P98155) and blocks apoE4 binding. Purified by immobilized Protein A. IgG1 class.
References:
Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms. Mikhailenko I et al. Journal of Cell Science 112, 3269-3281 (1999).
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. Ruiz J et al. Journal of Lipid Research 46, 1721-1731 (2005).
Gene Name: VLDLR
Gene ID: 7436
Swiss-Prot/UniProt ID: P98155