Like Cathepsins B, H, and L, Cathepsin S belongs to the group of lysosomal cysteine proteases. Cathepsin S is found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides. Cathepsin S activity is detected using Z-Val-Val-Arg-AMC (Bachem: I-1540). Prepared from tissue shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE.
Gene Name: CTSS
Gene ID: 1520
Swiss-Prot/UniProt ID: P25774