A single mutation at the P1 position of PAI-1 alters the target specificity of PAI-1 from the plasminogen activators tPA and uPA to Cathepsin G. This mutant contains a P1 Phenylalanine in place of the wild type Arginine residue (R346F) resulting in an inhibitor with the specificity of antichymotrypsin.
Gene Name: SERPINE1
Gene ID: 5054
Swiss-Prot/UniProt ID: P05121