This human PAI-1 variant contains a mutation at the active site to make it specific for inhibition of neutrophil elastase (R346V). Additional mutations provide resistance to cleavage (V343A) and increased stability (I91L). This preparation has low endotoxin (<20 EU/mg) so is suitable for in vivo studies.
Gene Name: SERPINE1
Gene ID: 5054
Swiss-Prot/UniProt ID: P05121