Mutagenesis of the P9 serine residue (Ser338) on the reactive center loop of human PAI-1 stable mutant (K154T, Q319L, M354I and N150H) to cysteine followed by incorporation of NBD has produced a reporter PAI-1 with extended half life. The properties of this interesting new reagent have not been fully characterized.
Gene Name: SERPINE1
Gene ID: 5054
Swiss-Prot/UniProt ID: P05121