The human form of PAI-1 contains the following four mutations: K154T, Q319L, M354I and N150H. These mutations combine to confer great stability to the otherwise labile molecule essentially locking in into the active conformation. It is an ideal choice for in vivo studies.
Gene Name: SERPINE1
Gene ID: 5054
Swiss-Prot/UniProt ID: P05121


Citations:
1. Minor, K.H. et al. (2005) J. Biol. Chem. 280: 28711-28720.
2 . Schar, C.R. et al. (2008) J. Biol. Chem. 283: 10297-10309.
3. Horowitz, J.C. et al. (2008) Am. J. Respir. Cell Mol. Biol. 38: 78-87.
4. Zhang, Y. et al. (2007) J. Immunol. 179: 3297-3304.
5. Crandall, D.L. et al. (2006) Arterioscler. Thromb. Vasc. Biol. 26:2209-2215.
6. Yang, D. et al. (2009) J. Neurosci. 29:8669-8674.