Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Found in plasma at about 70 ug per ml. Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion.
Gene Name: SERPINF2
Gene ID: 5345
Swiss-Prot/UniProt ID: P08697


Citations:
Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype. Simon Allard, Wanda C. Leon, Prateep Pakavathkumar, Martin A. Bruno, Alfredo Ribeiro-da-Silva, and A. Claudio Cuello. J. Neurosci., Feb 2012; 32: 2002 - 2012.