Human PAI-1 (stable vitronectin binding negative mutant)

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Product Description

Human PAI-1 (stable vitronectin binding negative mutant)

A double mutation (Q123K and R101A) on the human PAI-1 stable mutant background (K154T, Q319L, M354I and N150H) results in PAI-1 with a greatly extended half life and greatly reduced binding to the important ligand vitronectin.
References
Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal. Jensen JK, Durand MK, Skeldal S, Dupont DM, Bødker JS, Wind T, Andreasen PA. FEBS Lett. 2004 Jan 2;556(1-3):175-9.
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1. Zhi Xu, Rashna D. Balsara, Natalia V. Gorlatova, Daniel A. Lawrence, Francis J. Castellino, and Victoria A. Ploplis. J. Biol. Chem., Apr 2004; 279:17914-20.

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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1. Wan YZ, Gao P, Zhou S, et al. SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. Aging Cell. 2014;13(5):890-9. link to article